| http://purl.uniprot.org/citations/7520084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7520084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7520084 | http://www.w3.org/2000/01/rdf-schema#comment | "The three-dimensional structure of the complex of a second anti-peptide antibody (Fab 26/9) that recognizes the same six-residue epitope of an immunogenic peptide from influenza virus hemagglutinin (HA1; 75-110) as Fab 17/9 with the peptide has been determined at 2.8 A resolution. The amino acid sequence of the variable region of the 26/9 antibody differs in 24 positions from that of 17/9, the first antibody in this series for which several ligand-bound and free structures have been determined and refined. Comparison of the 26/9-peptide with the 17/9-peptide complex structures shows that the two Fabs are very similar (r.m.s.d. 0.5 to 0.8 A) and that the peptide antigen (101-107) has virtually the same conformation (r.m.s.d. 0.3 to 0.8 A) when bound to both antibodies. A sequence difference in the 26/9 binding pocket (L94; His in 26/9, Asn in 17/9) results in an interaction with a bound water molecule that is not seen in the 17/9 structures. Epitope mapping shows that the relative specificity of 26/9 and 17/9 antibodies for individual positions of the peptide antigen are slightly different. Amino acid substitutions in the peptide, particularly at position SerP107, are tolerated to different extents by 17/9 and 26/9. Structural and sequence analysis suggests that amino acid differences near the peptide-binding site are responsible for altering slightly the specificity of 26/9 for three peptide residues and illustrates how amino acid substitutions can modify antibody-antigen interactions and thereby modulate antibody specificity."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1994.1530"xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1994.1530"xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Stura E.A."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Stura E.A."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Schulze-Gahmen U."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Schulze-Gahmen U."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Wilson I.A."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Houghten R.A."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Houghten R.A."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Churchill M.E."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Churchill M.E."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Kono D.H."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Kono D.H."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Pinilla C."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Pinilla C."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Appel J.R."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Appel J.R."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Balderas R.S."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Balderas R.S."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Fieser G.G."xsd:string |
| http://purl.uniprot.org/citations/7520084 | http://purl.uniprot.org/core/author | "Fieser G.G."xsd:string |