| http://purl.uniprot.org/citations/7521686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7521686 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice lacking granulocyte colony-stimulating factor (G-CSF) were generated by targeted disruption of the G-CSF gene in embryonal stem cells. G-CSF-deficient mice (genotype G-CSF-/-) are viable, fertile, and superficially healthy, but have a chronic neutropenia. Peripheral blood neutrophil levels were 20% to 30% of wild-type mice (genotype G-CSF+/+) and mice heterozygous for the null mutation had intermediate neutrophil levels, suggesting a gene-dosage effect. In the marrow of G-CSF-/-mice, granulopoietic precursor cells were reduced by 50% and there were reduced levels of granulocyte, macrophage, and blast progenitor cells. Despite G-CSF deficiency, mature neutrophils were still present in the blood and marrow, indicating that other factors can support neutrophil production in vivo. G-CSF-/-mice had reduced numbers of neutrophils available for rapid mobilization into the circulation by a single dose of G-CSF. G-CSF administration reversed the granulopoietic defect of G-CSF-/-mice. One day of G-CSF administration to G-CSF-/-mice elevated circulating neutrophil levels to normal, and after 4 days of G-CSF administration, G-CSF+/+ and G-CSF-/-marrows were morphologically indistinguishable. G-CSF-/-mice had a markedly impaired ability to control infection with Listeria monocytogenes, with diminished neutrophil and delayed monocyte increases in the blood and reduced infection-driven granulopoiesis. Collectively, these observations indicate that G-CSF is indispensible for maintaining the normal quantitative balance of neutrophil production during "steady-state" granulopoiesis in vivo and also implicate G-CSF in "emergency" granulopoiesis during infections."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Stanley E."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Basu S."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Dunn A.R."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Hodgson G."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Metcalf D."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Fowler K.J."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Lieschke G.J."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Grail D."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Cheers C."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/author | "Zhan Y.F."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/pages | "1737-1746"xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/title | "Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization."xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://purl.uniprot.org/core/volume | "84"xsd:string |
| http://purl.uniprot.org/citations/7521686 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7521686 |
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| http://purl.uniprot.org/uniprot/#_Q3UM22-mappedCitation-7521686 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7521686 |
| http://purl.uniprot.org/uniprot/P09920 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7521686 |
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