http://purl.uniprot.org/citations/7525452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/7525452 | http://www.w3.org/2000/01/rdf-schema#comment | "The genes for insulin-like growth factor binding proteins (IGFBPs) encode secreted proteins that bind insulin-like growth factors I and II with high affinity and modulate their biological activities. In this report we have used interspecific backcross mapping and gene cloning to define the chromosomal locations of 4 mouse Igfbp genes. Igfbp1 and 3 are found in the proximal part of chromosome 1. In the human genome these two loci map within 20 kb of one another on chromosome 7p14-p12, and the genes are organized in a tail-to-tail configuration. Mouse Igfbp2 and 5 colocalize to a proximal region of chromosome 1 that is syntenic with human chromosome 2q33-q36, and the two genes are 5 kb apart in a tail-to-tail orientation. These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group."xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.1994.1329"xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/author | "Gilbert D.J."xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/author | "Rotwein P."xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/author | "James P.L."xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/author | "Clemmons D.R."xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/author | "Kou K."xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/pages | "653-655"xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/title | "Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11."xsd:string |
http://purl.uniprot.org/citations/7525452 | http://purl.uniprot.org/core/volume | "21"xsd:string |
http://purl.uniprot.org/citations/7525452 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7525452 |
http://purl.uniprot.org/citations/7525452 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7525452 |
http://purl.uniprot.org/uniprot/P24593#attribution-A384C5E17E9A3C08219003E0D076EBF7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7525452 |
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