| http://purl.uniprot.org/citations/7528218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7528218 | http://www.w3.org/2000/01/rdf-schema#comment | "The B cell-specific cell surface molecule CD19 plays a role in regulating immunoglobulin (Ig) receptor signaling, and cross-linking CD19 activates several signaling molecules in mature human B cells. In surface Ig-negative B cell precursors, a protein tyrosine kinase (PTK)-dependent homotypic aggregation response can be triggered by cross-linking CD19. In the current study, we examined the outcome of PTK-mediated signal transduction following CD19 cross-linking on surface Ig negative and surface Ig positive B cell lines, as well as freshly isolated surface Ig-negative B cell precursors. PTK activation resulted in the tyrosine phosphorylation of multiple protein substrates and peaked at 0.5-1 min following CD19 cross-linking in all B-lineage cells examined. One of the tyrosine-phosphorylated substrates was identified as the hematopoietic-specific protein Vav, a guanine nucleotide exchange factor that activates the Ras pathway. Evidence consistent with Ras pathway activation was also demonstrated by MEK activation and subsequent phosphorylation of a MAP kinase fusion protein. CD19 cross-linking, sequential immunoprecipitation, and Western blotting revealed that: (a) Vav becomes associated with CD19, (b) phosphatidylinositol 3-kinase (PI 3-kinase) becomes associated with CD19, and (c) PI 3-kinase becomes associated with Vav. No such physical interaction occurred following control IgG1 cross-linking or cross-linking of class I major histocompatability complex cell surface molecules. Coupled with a previous report (Tuveson, D.A., Carter, R.H., Soltoff, S.P., and Fearon, D.T. (1993) Science 260, 986-988), our data support a model in which CD19 cross-linking induces the formation of a signaling complex that leads to the activation of two pathways involving Ras and PI 3-kinase."xsd:string |
| http://purl.uniprot.org/citations/7528218 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)31664-8"xsd:string |
| http://purl.uniprot.org/citations/7528218 | http://purl.uniprot.org/core/author | "LeBien T.W."xsd:string |
| http://purl.uniprot.org/citations/7528218 | http://purl.uniprot.org/core/author | "Jarvis L."xsd:string |
| http://purl.uniprot.org/citations/7528218 | http://purl.uniprot.org/core/author | "Weng W.K."xsd:string |
| http://purl.uniprot.org/citations/7528218 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7528218 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/7528218 | http://purl.uniprot.org/core/pages | "32514-32521"xsd:string |
| http://purl.uniprot.org/citations/7528218 | http://purl.uniprot.org/core/title | "Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors."xsd:string |
| http://purl.uniprot.org/citations/7528218 | http://purl.uniprot.org/core/volume | "269"xsd:string |
| http://purl.uniprot.org/citations/7528218 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7528218 |
| http://purl.uniprot.org/citations/7528218 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7528218 |
| http://purl.uniprot.org/uniprot/#_P15391-mappedCitation-7528218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7528218 |
| http://purl.uniprot.org/uniprot/#_O00329-mappedCitation-7528218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7528218 |
| http://purl.uniprot.org/uniprot/#_P27986-mappedCitation-7528218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7528218 |
| http://purl.uniprot.org/uniprot/#_P15498-mappedCitation-7528218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7528218 |
| http://purl.uniprot.org/uniprot/#_P62993-mappedCitation-7528218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7528218 |
| http://purl.uniprot.org/uniprot/P15391 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7528218 |
| http://purl.uniprot.org/uniprot/P15498 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7528218 |
| http://purl.uniprot.org/uniprot/O00329 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7528218 |
| http://purl.uniprot.org/uniprot/P27986 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7528218 |
| http://purl.uniprot.org/uniprot/P62993 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7528218 |