| http://purl.uniprot.org/citations/7530745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7530745 | http://www.w3.org/2000/01/rdf-schema#comment | "Astrocytes in the central nervous system (CNS) associate intimately with vascular endothelial cells and are integral to the blood-brain barrier (BBB). Leukocyte transmigration across the BBB is a cardinal feature of CNS inflammation, as observed in experimental autoimmune encephalomyelitis, and very late antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) interactions have recently been proposed as essential for this process. VCAM-1 expression by astrocytes was recently reported. We addressed the regulation of VCAM-1 expression by inflammatory cytokines in primary human astrocytes and two human astrocytoma cell lines. Astrocytoma cells up-regulated surface VCAM-1 expression in response to cytokines in the following order: IFN-gamma plus TNF-alpha > IFN-gamma plus IL-1 beta > TNF-alpha > IFN-gamma. Cytokine-activated astrocytoma cells expressed 7-domain VCAM-1, as indicated by accumulation of 3.2-kb VCAM-1 mRNA and immunoprecipitation of a 100-kDa protein with anti-VCAM-1 mAb. Lymphoblast adhesion to cytokine-activated astrocytoma cell monolayers was significantly blocked by mAb specific for VCAM-1 and VLA-4, indicating that astrocytoma cell VCAM-1 was functional. Astrocytoma cell expression of VCAM-1 could be a constituent of the astrocyte phenotype. To support this possibility, we demonstrated that cytokine-treated adult human and rat primary astrocytes expressed VCAM-1, and the rank order of cytokine potency for VCAM-1 induction in primary and neoplastic astrocytes was strikingly similar. This is the first documentation of VCAM-1 expression by adult human astrocytes. Expression of VCAM-1 by astrocytes at the BBB could play a role in mononuclear leukocyte entry into the CNS."xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/author | "Ransohoff R.M."xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/author | "Benveniste E.N."xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/author | "Shrikant P."xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/author | "Dubb L."xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/author | "Rosenman S.J."xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/pages | "1888-1899"xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/title | "Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines."xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/7530745 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7530745 |
| http://purl.uniprot.org/citations/7530745 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7530745 |
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| http://purl.uniprot.org/uniprot/#_P13747-mappedCitation-7530745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7530745 |
| http://purl.uniprot.org/uniprot/#_P13762-mappedCitation-7530745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7530745 |
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| http://purl.uniprot.org/uniprot/#_Q14134-mappedCitation-7530745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7530745 |
| http://purl.uniprot.org/uniprot/#_Q14142-mappedCitation-7530745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7530745 |
| http://purl.uniprot.org/uniprot/#_Q14258-mappedCitation-7530745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7530745 |
| http://purl.uniprot.org/uniprot/#_Q15646-mappedCitation-7530745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7530745 |
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| http://purl.uniprot.org/uniprot/#_P79483-mappedCitation-7530745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7530745 |