| http://purl.uniprot.org/citations/7533895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7533895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7533895 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription factor IIH (TFIIH) contains a kinase capable of phosphorylating the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAPII). Here we report the identification of the Cdk-activating kinase (Cak) complex (Cdk7 and cyclin H) as a component of TFIIH after extensive purification of TFIIH by chromatography. We find that affinity-purified antibodies directed against cyclin H inhibit TFIIH-dependent transcription and that both cyclin H and Cdk7 antibodies inhibit phosphorylation of the CTD of the largest subunit of the RNAPII in the preinitiation complex. Cak is present in at least two distinct complexes, TFIIH and a smaller complex that is unable to phosphorylate RNAPII in the preinitiation complex. Both Cak complexes, as well as recombinant Cak, phosphorylate a CTD peptide. Finally, TFIIH was shown to phosphorylate both Cdc2 and Cdk2, suggesting that there could be a link between transcription and the cell cycle machinery."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.org/dc/terms/identifier | "doi:10.1038/374283a0"xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.org/dc/terms/identifier | "doi:10.1038/374283a0"xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Morgan D.O."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Morgan D.O."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Drapkin R."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Drapkin R."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Shiekhattar R."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Shiekhattar R."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Fisher R.P."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Fisher R.P."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Dynlacht B."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Dynlacht B."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Mermelstein F."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Mermelstein F."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Wessling H.C."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/author | "Wessling H.C."xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7533895 | http://purl.uniprot.org/core/name | "Nature"xsd:string |