| http://purl.uniprot.org/citations/7538118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7538118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7538118 | http://www.w3.org/2000/01/rdf-schema#comment | "Syk is a cytoplasmic protein-tyrosine kinase containing two amino-terminal Src homology 2 domains that is activated following ligation of the B cell antigen receptor. Syk activation in B cells correlates with Syk tyrosine phosphorylation as well as with Syk SH2-mediated association with the tyrosine-phosphorylated Ig alpha and Ig beta B cell antigen receptor subunits. Tyrosine-phosphorylated peptide 20-mers representing Ig alpha and Ig beta immunoreceptor tyrosine activation motifs were synthesized and found to stimulate the specific activity of Syk by as much as 10-fold in vitro. Maximal phosphopeptide-induced Syk activation required both Syk SH2 domains and phosphorylation of both tyrosine residues present in the immunoreceptor tyrosine activation motif. The biochemical mechanism responsible for the phosphopeptide-induced Syk enzyme activation appears to be a function of Syk autophosphorylation. Our observations suggest the association of Syk tandem SH2 domains with the tyrosine-phosphorylated Ig alpha and/or Ig beta immunoreceptor tyrosine activation motifs in B cells stimulates Syk autophosphorylation leading to Syk enzyme activation."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.19.11590"xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.19.11590"xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Bolen J.B."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Bolen J.B."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Burkhardt A.L."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Burkhardt A.L."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Rowley R.B."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Rowley R.B."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Chao H.-G."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Chao H.-G."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Matsueda G.R."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/author | "Matsueda G.R."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/pages | "11590-11594"xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/pages | "11590-11594"xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/title | "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/title | "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation."xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7538118 | http://purl.uniprot.org/core/volume | "270"xsd:string |