| http://purl.uniprot.org/citations/7538907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7538907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7538907 | http://www.w3.org/2000/01/rdf-schema#comment | "Using the cytoplasmic domain of Fas in the yeast two-hybrid system, we have identified a novel interacting protein, FADD, which binds Fas and Fas-FD5, a mutant of Fas possessing enhanced killing activity, but not the functionally inactive mutants Fas-LPR and Fas-FD8. FADD contains a death domain homologous to the death domains of Fas and TNFR-1. A point mutation in FADD, analogous to the lpr mutation of Fas, abolishes its ability to bind Fas, suggesting a death domain to death domain interaction. Overexpression of FADD in MCF7 and BJAB cells induces apoptosis, which, like Fas-induced apoptosis, is blocked by CrmA, a specific inhibitor of the interleukin-1 beta-converting enzyme. These findings suggest that FADD may play an important role in the proximal signal transduction of Fas."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(95)90071-3"xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(95)90071-3"xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/author | "O'Rourke K."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/author | "O'Rourke K."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/author | "Tewari M."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/author | "Tewari M."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/author | "Chinnaiyan A.M."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/author | "Chinnaiyan A.M."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/pages | "505-512"xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/pages | "505-512"xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/title | "FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/title | "FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis."xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/7538907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7538907 |
| http://purl.uniprot.org/citations/7538907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7538907 |