http://purl.uniprot.org/citations/7542404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/7542404 | http://www.w3.org/2000/01/rdf-schema#comment | "It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.7542404"xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Brennan P.J."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Bloom B.R."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Chatterjee D."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Kronenberg M."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Prigozy T.I."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Sieling P.A."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Brenner M.B."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Porcelli S.A."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Mazzaccaro R.J."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/author | "Soriano T."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/name | "Science"xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/pages | "227-230"xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/title | "CD1-restricted T cell recognition of microbial lipoglycan antigens."xsd:string |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/volume | "269"xsd:string |
http://purl.uniprot.org/citations/7542404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7542404 |
http://purl.uniprot.org/citations/7542404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7542404 |
http://purl.uniprot.org/citations/7542404 | http://purl.uniprot.org/core/authorsIncomplete | "true"xsd:boolean |
http://purl.uniprot.org/uniprot/#_A0A0A6YYK7-mappedCitation-7542404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7542404 |
http://purl.uniprot.org/uniprot/#_P61769-mappedCitation-7542404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7542404 |
http://purl.uniprot.org/uniprot/#_P04234-mappedCitation-7542404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7542404 |
http://purl.uniprot.org/uniprot/#_P01733-mappedCitation-7542404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7542404 |