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http://purl.uniprot.org/citations/7542404http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7542404http://www.w3.org/2000/01/rdf-schema#comment"It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.org/dc/terms/identifier"doi:10.1126/science.7542404"xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Brennan P.J."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Bloom B.R."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Chatterjee D."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Kronenberg M."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Prigozy T.I."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Sieling P.A."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Brenner M.B."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Porcelli S.A."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Mazzaccaro R.J."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/author"Soriano T."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/pages"227-230"xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/title"CD1-restricted T cell recognition of microbial lipoglycan antigens."xsd:string
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/volume"269"xsd:string
http://purl.uniprot.org/citations/7542404http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/7542404
http://purl.uniprot.org/citations/7542404http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/7542404
http://purl.uniprot.org/citations/7542404http://purl.uniprot.org/core/authorsIncomplete"true"xsd:boolean
http://purl.uniprot.org/uniprot/#_A0A0A6YYK7-mappedCitation-7542404http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7542404
http://purl.uniprot.org/uniprot/#_P61769-mappedCitation-7542404http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7542404
http://purl.uniprot.org/uniprot/#_P04234-mappedCitation-7542404http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7542404
http://purl.uniprot.org/uniprot/#_P01733-mappedCitation-7542404http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/7542404