| http://purl.uniprot.org/citations/7544002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7544002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7544002 | http://www.w3.org/2000/01/rdf-schema#comment | "She is a widely expressed adapter protein that plays an important role in signaling via a variety of cell surface receptors and has been implicated in coupling the stimulation of growth factor, cytokine, and antigen receptors to the Ras signaling pathway. She interacts with several tyrosine-phosphorylated receptors through its C-terminal SH2 domain, and one of the mechanisms of T-cell receptor-mediated Ras activation involves the interaction of the Shc SH2 domain with the tyrosine-phosphorylated zeta chain of the T-cell receptor. Here we describe a high-resolution NMR structure of the Shc SH2 domain complexed to a phosphopeptide (GHDGLpYQGLSTATK) corresponding to a portion of the zeta chain of the T-cell receptor. Although the overall architecture of the protein is similar to other SH2 domains, distinct structural differences were observed in the smaller beta-sheet, BG loop, (pY + 3) phosphopeptide-binding site, and relative position of the bound phosphopeptide."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.17.7784"xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.17.7784"xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Yoon H.S."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Yoon H.S."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Fesik S.W."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Fesik S.W."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Ravichandran K.S."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Ravichandran K.S."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Zhou M.-M."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Zhou M.-M."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Burakoff S.J."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Burakoff S.J."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Logan T.M."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Logan T.M."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Meadows R.P."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Meadows R.P."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Wade W.S."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/author | "Wade W.S."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7544002 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |