| http://purl.uniprot.org/citations/7546294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7546294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7546294 | http://www.w3.org/2000/01/rdf-schema#comment | "The RAD6/UBC2 gene from Saccharomyces cerevisiae encodes a ubiquitin-conjugating enzyme involved in DNA repair, induced mutagenesis, and sporulation. Here we report the isolation and characterization of the Caenorhabditis elegans RAD6 homolog designated ubc-1. Ubc-1 encodes a 21.5-kD protein that shares considerable identity with RAD6 (66%) as well as with other RAD6 homologs, including Schizosaccharomyces pombe rhp6+ (70%), Drosophila melanogaster Dhr6 (83%), and the two human homologs HHR6A and HHR6B (84% and 83%, respectively). However, UBC-1 is distinct in being the only known RAD6 homolog, other than RAD6 itself, with a carboxy-terminal extension. Analysis of UBC-1 homologs from C. briggsae and Ascaris suum show that the presence of the carboxy-terminal extension is conserved in nematodes. When constitutively expressed from the yeast promoter ADH1, ubc-1 complements the DNA repair functions in a S. cerevisiae rad6 delta mutant. Surprisingly, ubc-1 fails to complement the sporulation function of RAD6, despite its possession of an acidic carboxy-terminal tail. C. elegans UBC-1 is capable of forming a thiol-ester bond with ubiquitin, but, unlike RAD6, is unable to transfer ubiquitin to histone H2B in vitro. Both cis and trans splicing are involved in the maturation of the ubc-1 transcript. The presence of the SL2 trans-splice leader in the ubc-1 transcript suggests that ubc-1 may be co-transcribed as part of a polycistronic message."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.org/dc/terms/identifier | "doi:10.1089/dna.1995.14.883"xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.org/dc/terms/identifier | "doi:10.1089/dna.1995.14.883"xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/author | "Jones D."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/author | "Jones D."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/author | "Leggett D.S."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/author | "Leggett D.S."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/author | "Candido E.P.M."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/author | "Candido E.P.M."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/name | "DNA Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/name | "DNA Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/pages | "883-891"xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/pages | "883-891"xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans UBC-1, a ubiquitin-conjugating enzyme homologous to yeast RAD6/UBC2, contains a novel carboxy-terminal extension that is conserved in nematodes."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans UBC-1, a ubiquitin-conjugating enzyme homologous to yeast RAD6/UBC2, contains a novel carboxy-terminal extension that is conserved in nematodes."xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/7546294 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7546294 |
| http://purl.uniprot.org/citations/7546294 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7546294 |
| http://purl.uniprot.org/citations/7546294 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7546294 |
| http://purl.uniprot.org/citations/7546294 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7546294 |