| http://purl.uniprot.org/citations/7560085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7560085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7560085 | http://www.w3.org/2000/01/rdf-schema#comment | "The number and exact locations of the major histocompatibility complex (MHC)-linked diabetogenic genes (Idd-1) are unknown because of strong linkage disequilibrium within the MHC. By using a congenic NOD mouse strain that possesses a recombinant MHC from a diabetes-resistant sister strain, we have now shown that Idd-1 consists of at least two components, one in and one outside the class II A and E regions. A new susceptibility gene (Idd-16) was mapped to the < 11-centiMorgan segment of chromosome 17 adjacent to, but distinct from, previously known Idd-1 candidates, class II A, E, and Tap genes. The coding sequences and splicing donor and acceptor sequences of the Tnfa gene, a candidate gene for Idd-16, were identical in the NOD, CTS, and BALB/c alleles, ruling out amino acid changes in the TNF molecule as a determinant of insulin-dependent diabetes mellitus susceptibility. Our results not only map a new MHC-linked diabetogenic gene(s) but also suggest a new way to fine map disease susceptibility genes within a region where strong linkage disequilibrium exists."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci118239"xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci118239"xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Makino S."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Makino S."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Kawaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Kawaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Ogihara T."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Ogihara T."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Sakamoto T."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Sakamoto T."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Ueda H."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Ueda H."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Ikegami H."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Ikegami H."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Takekawa K."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Takekawa K."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Yamato E."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/author | "Yamato E."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/name | "J. Clin. Invest."xsd:string |
| http://purl.uniprot.org/citations/7560085 | http://purl.uniprot.org/core/name | "J. Clin. Invest."xsd:string |