| http://purl.uniprot.org/citations/7566156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7566156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7566156 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) is the prototype for a family of extracellular polypeptides that affect cell proliferation and differentiation, and tissue morphogenesis. TGF-beta signalling is mediated by two types of serine/threonine kinase receptors, the type I and II receptors, which are able to form a heteromeric complex. No cytoplasmic proteins that associate with these receptors in vivo, or are their kinase targets, have yet been described. We have now identified a WD-domain-containing protein, TRIP-1, which specifically associates with the type II TGF-beta receptor in a kinase-dependent way. TRIP-1 does not interact with the type II activin or type I receptors, but associates with the heteromeric TGF-beta receptor complex. TRIP-1 is phosphorylated on serine and threonine by the receptor kinase, strongly suggesting that it has a role in TGF-beta signalling. This is supported by coexpression of TRIP-1 and type II receptor during development. The existence of TRIP-1 homologues in plant and yeast suggests a conserved function in all eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.org/dc/terms/identifier | "doi:10.1038/377548a0"xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.org/dc/terms/identifier | "doi:10.1038/377548a0"xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Derynck R."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Derynck R."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Chen R.H."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Chen R.H."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Choy L."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Choy L."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Maruka E.M."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Maruka E.M."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Miettinen P.J."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/author | "Miettinen P.J."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/pages | "548-552"xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/pages | "548-552"xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/title | "A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/title | "A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor."xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/volume | "377"xsd:string |
| http://purl.uniprot.org/citations/7566156 | http://purl.uniprot.org/core/volume | "377"xsd:string |