| http://purl.uniprot.org/citations/7568093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7568093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7568093 | http://www.w3.org/2000/01/rdf-schema#comment | "Vinculin, a major constituent of focal adhesions and zonula adherens junctions, is thought to be involved in linking the microfilaments to areas of cell-substrate and cell-cell contacts. To test the role of vinculin in cell adhesion and motility, we used homologous recombination to generate F9 embryonal carcinoma and embryonic stem cell clones homozygous for a disrupted vinculin gene. When compared to wild-type cells, vinculin-mutant cells displayed a rounder morphology and a reduced ability to adhere and spread on plastic or fibronectin. Decreased adhesion of the mutant cells was associated with a reduction in lamellipodial extensions, as observed by time-lapse video microscopy. The locomotive activities of control F9 and the vinculin-null cells were compared in two assays. Loss of vinculin resulted in a 2.4-fold increase in cell motility. These results demonstrate an important role for vinculin in determining cell shape, adhesion, surface protrusive activity, and cell locomotion."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.20.9161"xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.92.20.9161"xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Coll J.-L."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Coll J.-L."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Oshima R.G."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Oshima R.G."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Baribault H."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Baribault H."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Ben-Ze'ev A."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Ben-Ze'ev A."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Adamson E.D."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Adamson E.D."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Ezzell R.M."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Ezzell R.M."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Rodriguez Fernandez J.L."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/author | "Rodriguez Fernandez J.L."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/pages | "9161-9165"xsd:string |
| http://purl.uniprot.org/citations/7568093 | http://purl.uniprot.org/core/pages | "9161-9165"xsd:string |