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http://purl.uniprot.org/citations/7575502http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7575502http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7575502http://www.w3.org/2000/01/rdf-schema#comment"The molecular complex formed by the immunosuppressant FK506 and the immunophilin protein FKBP12 potently inhibits the Ca2+/calmodulin-activated protein phosphatase calcineurin. This mechanism appears to be common to all types of cell, implying that fundamental physiological modes of calcineurin regulation are exploited by immunosuppressants. The present paper describes a novel adenylyl cyclase regulated by calcineurin that contains an FKBP12-like domain and may thus constitute a physiologically relevant calcineurin docking site mimicked by immunosuppressant-immunophilin complexes. The enzyme messenger RNA is particularly enriched in the cerebral cortex, striatum and hippocampus, where it is localized to neuronal perikarya, indicative of an important role in neuronal function."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.1995.2385"xsd:string
http://purl.uniprot.org/citations/7575502http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.1995.2385"xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/author"Smith S.M."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/author"Smith S.M."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/author"Antoni F.A."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/author"Antoni F.A."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/author"Harmar A.J."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/author"Harmar A.J."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/author"Paterson J.M."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/author"Paterson J.M."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/pages"1000-1008"xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/pages"1000-1008"xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/title"Control of a novel adenylyl cyclase by calcineurin."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/title"Control of a novel adenylyl cyclase by calcineurin."xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/volume"214"xsd:string
http://purl.uniprot.org/citations/7575502http://purl.uniprot.org/core/volume"214"xsd:string
http://purl.uniprot.org/citations/7575502http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/7575502
http://purl.uniprot.org/citations/7575502http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/7575502