| http://purl.uniprot.org/citations/7577806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7577806 | http://www.w3.org/2000/01/rdf-schema#comment | "We have bred to homozygosity gene disruptions for the transporter associated with antigen processing 1 (TAP1) and beta 2-microglobulin (beta 2m), each of which plays a distinct role in providing class I MHC subunits. Surface expression of H-2Kb or Db on cells derived from TAP1/beta 2m -/-mice was undetectable by immunofluorescence or immunoprecipitation, unlike the situation observed for TAP1 -/- and beta 2m -/-single mutant mice. Yet, TAP1/beta 2m -/-cells were able to elicit a CD8+ cytotoxic T cell (CTL) response in mice of different H-2 haplotypes and could be killed by anti-H-2b specific CTL. Furthermore, TAP1/beta 2m -/-skin grafts were rejected by bm1 mutant mice. This suggests that very low levels of conformed class I heavy chains can reach the cell surface even in the complete absence of TAP1 and beta 2m gene products, and that these molecules may select a functional CD8+ T cell repertoire. Indeed, CD4-CD8+ T cells were detected in TAP1/beta 2m -/-mice, but in numbers lower than in either of the single mutant mice. Nonetheless, it was possible to elicit a CD8+ allospecific and H-2b reactive CTL response in TAP1/beta 2m -/- mice. In line with this, TAP1/beta 2m -/-mice rapidly rejected TAP1/beta 2m +/-skin grafts. Our results suggest that some MHC class I heavy chains in TAP1/beta 2m -/-cells can reach the cell surface in a form that allows recognition by allospecific CTL and positive selection of CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/7.6.975"xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/author | "Ploegh H.L."xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/author | "Ljunggren H.G."xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/author | "Tonegawa S."xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/author | "Auchincloss H. Jr."xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/author | "Sabatine M.S."xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/pages | "975-984"xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/title | "MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice."xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/7577806 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7577806 |
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| http://purl.uniprot.org/uniprot/#_F6QHF1-mappedCitation-7577806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7577806 |
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| http://purl.uniprot.org/uniprot/#_Q62428-mappedCitation-7577806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7577806 |
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| http://purl.uniprot.org/uniprot/#_Q64333-mappedCitation-7577806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7577806 |
| http://purl.uniprot.org/uniprot/#_Q3U6V4-mappedCitation-7577806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7577806 |
| http://purl.uniprot.org/uniprot/#_P01887-mappedCitation-7577806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7577806 |
| http://purl.uniprot.org/uniprot/#_P21958-mappedCitation-7577806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7577806 |