| http://purl.uniprot.org/citations/7588220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7588220 | http://www.w3.org/2000/01/rdf-schema#comment | "In muscular dystrophy there is an imbalance between muscle protein synthesis and protein degradation, resulting in net muscle catabolism and progressive muscle weakness and wasting. Both insulin and insulin-like growth factor I (IGF-I) are known to have an anabolic effect on skeletal muscle, which is believed to be enhanced in the presence of elevated concentrations of amino acids. We examined the effects of 4-week administration of recombinant human IGF-I (rhIGF-I), both alone and supplemented with a high protein diet (HPD), on muscle metabolism, morphology, and function in the 129 ReJ dystrophic mouse. rhIGF-I significantly reduced muscle protein degradation (P < 0.001), increased muscle protein content (P < 0.05), decreased fiber area variability (P < 0.01), and increased hind limb utilization (P < 0.01). Supplementation of rhIGF-I therapy with a HPD resulted in a significant increase in muscle protein synthesis (P < 0.05) in addition to a further increase in the above parameters. We conclude that rhIGF-I causes an improvement in muscle metabolism, morphology, and function in dystrophic mice, and this effect is further enhanced by the presence of a HPD."xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.org/dc/terms/identifier | "doi:10.1210/endo.136.11.7588220"xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/author | "O'Connor M."xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/author | "Slonim A.E."xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/author | "Moyse J."xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/author | "Teichberg S."xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/author | "Wingertzahn M.A."xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/author | "Zdanowicz M.M."xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/pages | "4880-4886"xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/title | "Effect of insulin-like growth factor I in murine muscular dystrophy."xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/7588220 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7588220 |
| http://purl.uniprot.org/citations/7588220 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7588220 |
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