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http://purl.uniprot.org/citations/7588819http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7588819http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7588819http://www.w3.org/2000/01/rdf-schema#comment"One of the characteristics of the host defense of higher insects is the rapid and transient synthesis of a variety of potent antimicrobial peptides. To date, several distinct inducible antimicrobial peptides or peptide families have been totally or partially characterized. We present here the isolation and characterization of a novel 26-residue proline-rich immune-inducible peptide from Drosophila, which exhibits both antibacterial (Gram-positive) and antifungal activities. Peptide sequencing and cDNA cloning indicate the presense of two isoforms in our Drosophila Oregon strain, which differ by one residue (His compared to Arg) as a consequence of a single nucleotide change. The gene, which maps in position 52A1-2 on the right arm of the second chromosome, is expressed in the fat body after immune challenge. The novel peptide, which we propose to name metchnikowin, is a member of a family of proline-rich peptides, and we discuss the possible evolutionary relationships within this family."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.org/dc/terms/identifier"doi:10.1111/j.1432-1033.1995.694_2.x"xsd:string
http://purl.uniprot.org/citations/7588819http://purl.org/dc/terms/identifier"doi:10.1111/j.1432-1033.1995.694_2.x"xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Levashina E.A."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Levashina E.A."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Bulet P."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Bulet P."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Hetru C."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Hetru C."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Hoffmann J.A."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Hoffmann J.A."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Reichhart J.-M."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Reichhart J.-M."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Ohresser S."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/author"Ohresser S."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/name"Eur. J. Biochem."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/name"Eur. J. Biochem."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/pages"694-700"xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/pages"694-700"xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/title"Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties."xsd:string
http://purl.uniprot.org/citations/7588819http://purl.uniprot.org/core/title"Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties."xsd:string