| http://purl.uniprot.org/citations/7592531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7592531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7592531 | http://www.w3.org/2000/01/rdf-schema#comment | "We isolated the structural gene encoding cytochrome P-450 aromatase (P-450arom), for the first time from a nonmammalian vertebrate, the medaka (a teleost fish, Oryzias latipes), using the rainbow trout P-450arom cDNA as a probe. The structure of the entire P-450arom gene, the nucleotide sequence of its 5' flanking region, and the transcriptional initiation sites were determined. The medaka P-450arom gene consists of nine exons, but spans only 2.6 kb, being much smaller than the human P-450arom gene (at least 70 kb), as a result of extremely small introns (medaka, 73-213 bp vs. human, 1.3-10 kbp). The splicing junctions are located at exactly the same positions as those found in the human P-450arom. The deduced amino acid sequence is 51-52% identical to those of mammals and chicken, and 75% identical to the rainbow trout amino acid sequence. Genomic Southern blots revealed the presence of a single medaka gene. Promoter analyses indicated two major transcription initiation sites 60 and 61 bp upstream from a putative initiation codon. The promoter region of medaka P-450arom gene also contains potential Ad4BP sites and estrogen responsive element (ERE) half-sites. These results suggest that the basic structural organization of P-450arom genes and the regulatory mechanisms of expression are well conserved throughout the vertebrates."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.org/dc/terms/identifier | "doi:10.1093/oxfordjournals.jbchem.a124768"xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.org/dc/terms/identifier | "doi:10.1093/oxfordjournals.jbchem.a124768"xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/author | "Matsuyama M."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/author | "Matsuyama M."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/author | "Nagahama Y."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/author | "Nagahama Y."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/author | "Fukada S."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/author | "Fukada S."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/name | "J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/name | "J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/pages | "719-725"xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/pages | "719-725"xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/title | "Structure and promoter analysis of the cytochrome P-450 aromatase gene of the teleost fish, medaka (Oryzias latipes)."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/title | "Structure and promoter analysis of the cytochrome P-450 aromatase gene of the teleost fish, medaka (Oryzias latipes)."xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/7592531 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7592531 |
| http://purl.uniprot.org/citations/7592531 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7592531 |