| http://purl.uniprot.org/citations/7592771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7592771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7592771 | http://www.w3.org/2000/01/rdf-schema#comment | "The syntrophin family of dystrophin-associated proteins consists of three isoforms, alpha 1, beta 1, and beta 2, each encoded by a distinct gene. We have cloned and characterized the mouse alpha 1- and beta 2-syntrophin genes. The mouse alpha 1-syntrophin gene ( > 24 kilobases) is comprised of eight exons. The mouse beta 2-syntrophin gene ( > 33 kilobases) contains seven exons, all of which have homologues at the corresponding position in the alpha 1-syntrophin gene. Primer extension analysis reveals two transcription initiation sites in the alpha 1-syntrophin gene and a single site in the beta 2-syntrophin gene. The sequence immediately 5' of the transcription start sites of both genes lacks a TATA box but is GC-rich and has multiple putative SP1 binding sites. The alpha 1-syntrophin gene is located on human chromosome 20 and mouse chromosome 2, while the beta 2-syntrophin gene is on human chromosome 16 and mouse chromosome 8. Analysis of the amino acid sequence of the syntrophins reveals the presence of four conserved domains. The carboxyl-terminal 56 amino acids are highly conserved and constitute a syntrophin unique domain. Two pleckstrin homology domains are located at the amino-terminal end of the protein. The first pleckstrin homology domain is interrupted by a domain homologous to repeated sequences originally found in the Drosophila discs-large protein."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.43.25859"xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.43.25859"xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "Adams M.E."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "Adams M.E."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "White R.A."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "White R.A."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "Froehner S.C."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "Froehner S.C."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "Dowler L.L."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "Dowler L.L."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "Dwyer T.M."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/author | "Dwyer T.M."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/pages | "25859-25865"xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/pages | "25859-25865"xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/title | "Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome localization, and homology with a discs large domain."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/title | "Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome localization, and homology with a discs large domain."xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7592771 | http://purl.uniprot.org/core/volume | "270"xsd:string |