| http://purl.uniprot.org/citations/7592992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7592992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7592992 | http://www.w3.org/2000/01/rdf-schema#comment | "Dystrophin, the product of the Duchenne muscular dystrophy gene, is tightly associated with the sarcolemmal membrane to a large glycoprotein complex. One function of the dystrophin-glycoprotein complex is to link the cytoskeleton to the extracellular matrix in skeletal muscle. However, the molecular interactions of dystrophin with the membrane components of the dystrophin-glycoprotein complex are still elusive. Here, we demonstrate and characterize a specific interaction between beta-dystroglycan and dystrophin. We show that skeletal muscle and brain dystrophin as well as brain dystrophin isoforms specifically bind to beta-dystroglycan. To localize and characterize the dystrophin and beta-dystroglycan interaction domains, we reconstituted the interaction in vitro using dystrophin fusion proteins and in vitro translated beta-dystroglycan. We demonstrated that the 15 C-terminal amino acids of beta-dystroglycan constituted a unique binding site for the second half of the hinge 4 and the cysteine-rich domain of dystrophin (amino acids 3054-3271). This dystrophin binding site is located in a proline-rich environment of beta-dystroglycan within amino acids 880-895. The identification of the interaction sites in dystrophin and beta-dystroglycan provides further insight into the structure and the molecular organization of the dystrophin-glycoprotein complex at the sarcolemma membrane and will be helpful for studying the pathogenesis of Duchenne muscular dystrophy."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.45.27305"xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.45.27305"xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Meyer J."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Meyer J."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Jung D."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Jung D."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Campbell K.P."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Campbell K.P."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Chamberlain J.S."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/author | "Chamberlain J.S."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/pages | "27305-27310"xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/pages | "27305-27310"xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/title | "Identification and characterization of the dystrophin anchoring site on beta-dystroglycan."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/title | "Identification and characterization of the dystrophin anchoring site on beta-dystroglycan."xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7592992 | http://purl.uniprot.org/core/volume | "270"xsd:string |