| http://purl.uniprot.org/citations/7594523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7594523 | http://www.w3.org/2000/01/rdf-schema#comment | "Granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-3 are generally thought to be produced in a coordinated fashion by all activated T cells. We have examined this premise using quantitative kinetic analyses of the expression of GM-CSF and IL-3 in clonal cultures of mouse T cells for the first two weeks following in vitro stimulation with solid-phase TCR- and accessory molecule-specific mAbs. We demonstrate that 1) differential secretion of GM-CSF and IL-3 is a feature of high proportions of CD8+ and CD4+ T cell clones, for extended periods of time following activation; 2) multiple patterns of expression of these two cytokines can occur, including equivalent, GM-CSF-biased, and IL-3-biased production, and a pattern that switches over a period of days from GM-CSF-biased to IL-3-biased production; 3) the disparate relative levels of secretion are not due to differential consumption of either cytokine; 4) altered T cell activation by addition of CD28 costimulation accelerates both GM-CSF and IL-3 production but biased patterns of expression are retained, and 5) most T cells are not pre-committed to a particular pattern of relative GM-CSF and IL-3 expression; instead, the potential for multiple patterns may persist for several days following in vitro activation. The results indicate that T cells have the potential to display previously unrecognized diversity of expression of GM-CSF and IL-3."xsd:string |
| http://purl.uniprot.org/citations/7594523 | http://purl.uniprot.org/core/author | "Kelso A."xsd:string |
| http://purl.uniprot.org/citations/7594523 | http://purl.uniprot.org/core/author | "Fitzpatrick D.R."xsd:string |
| http://purl.uniprot.org/citations/7594523 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7594523 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/7594523 | http://purl.uniprot.org/core/pages | "5140-5150"xsd:string |
| http://purl.uniprot.org/citations/7594523 | http://purl.uniprot.org/core/title | "Dissociated expression of granulocyte-macrophage CSF and IL-3 in short-term T cell clones from normal mice."xsd:string |
| http://purl.uniprot.org/citations/7594523 | http://purl.uniprot.org/core/volume | "155"xsd:string |
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