| http://purl.uniprot.org/citations/7596436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7596436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7596436 | http://www.w3.org/2000/01/rdf-schema#comment | "The vascular endothelial growth factor (VEGF) and its high-affinity binding receptors, the tyrosine kinases Flt-1 and Flk-1, are thought to be important for the development of embryonic vasculature. Here we report that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation. Mouse embryos homozygous for a targeted mutation in the flt-1 locus, flt-1lcz, formed endothelial cells in both embryonic and extra-embryonic regions, but assembled these cells into abnormal vascular channels and died in utero at mid-somite stages. At earlier stages, the blood islands of flt-1lcz homozygotes were abnormal, with angioblasts in the interior as well as on the periphery. We suggest that the Flt-1 signalling pathway may regulate normal endothelial cell-cell or cell-matrix interactions during vascular development."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.org/dc/terms/identifier | "doi:10.1038/376066a0"xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.org/dc/terms/identifier | "doi:10.1038/376066a0"xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/author | "Gertsenstein M."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/author | "Gertsenstein M."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/author | "Rossant J."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/author | "Rossant J."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/author | "Breitman M.L."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/author | "Breitman M.L."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/author | "Fong G.H."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/author | "Fong G.H."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/pages | "66-70"xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/pages | "66-70"xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/title | "Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/title | "Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium."xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/volume | "376"xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://purl.uniprot.org/core/volume | "376"xsd:string |
| http://purl.uniprot.org/citations/7596436 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7596436 |
| http://purl.uniprot.org/citations/7596436 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7596436 |