| http://purl.uniprot.org/citations/7596437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7596437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7596437 | http://www.w3.org/2000/01/rdf-schema#comment | "Tie-1 and Tie-2 define a new class of receptor tyrosine kinases that are specifically expressed in developing vascular endothelial cells. To study the functions of Tie-1 and Tie-2 during vascular endothelial cell growth and differentiation in vivo, targeted mutations of the genes in mice were introduced by homologous recombination. Embryos deficient in Tie-1 failed to establish structural integrity of vascular endothelial cells, resulting in oedema and subsequently localized haemorrhage. However, analyses of embryos deficient in Tie-2 showed that it is important in angiogenesis, particularly for vascular network formation in endothelial cells. This result contrasts with previous reports on Tie-2 function in vasculogenesis and/or endothelial cell survival. Our in vivo analyses indicate that the structurally related receptor tyrosine kinases Tie-1 and Tie-2 have important but distinct roles in the formation of blood vessels."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.org/dc/terms/identifier | "doi:10.1038/376070a0"xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.org/dc/terms/identifier | "doi:10.1038/376070a0"xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Fujiwara Y."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Fujiwara Y."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Tozawa Y."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Tozawa Y."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Deutsch U."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Deutsch U."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Risau W."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Risau W."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Sato T.N."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Sato T.N."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Gendron-Maguire M."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Gendron-Maguire M."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Gridley T."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Gridley T."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Wolburg H."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Wolburg H."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Wolburg-Buchholz K."xsd:string |
| http://purl.uniprot.org/citations/7596437 | http://purl.uniprot.org/core/author | "Wolburg-Buchholz K."xsd:string |