| http://purl.uniprot.org/citations/7606779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7606779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7606779 | http://www.w3.org/2000/01/rdf-schema#comment | "Various diverse extracellular proteins possess Ca(2+)-binding epidermal growth factor (EGF)-like domains, the function of which remains uncertain. We have determined, at high resolution (1.5 A), the crystal structure of such a domain, from human clotting factor IX, as a complex with Ca2+. The Ca2+ ligands form a classic pentagonal bipyramid with six ligands contributed by one polypeptide chain and the seventh supplied by a neighboring EGF-like domain. The crystal structure identifies the role of Ca2+ in maintaining the conformation of the N-terminal region of the domain, but more importantly demonstrates that Ca2+ can directly mediate protein-protein contacts. The observed crystal packing of the domains provides a plausible model for the association of multiple tandemly linked EGF-like domains in proteins such as fibrillin-1, Notch, and protein S. This model is consistent with the known functional data and suggests a general biological role for these domains."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(95)90059-4"xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(95)90059-4"xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Rao Z."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Rao Z."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Stuart D."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Stuart D."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Brownlee G.G."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Brownlee G.G."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Handford P."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Handford P."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Knott V."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Knott V."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Mayhew M."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/author | "Mayhew M."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/pages | "131-141"xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/pages | "131-141"xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/title | "The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions."xsd:string |
| http://purl.uniprot.org/citations/7606779 | http://purl.uniprot.org/core/title | "The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions."xsd:string |