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| http://purl.uniprot.org/citations/7607066 | http://www.w3.org/2000/01/rdf-schema#comment | "During Caenorhabditis elegans male spicule development, four pairs of precursor cells respond to multiple positional cues and establish a pattern of fates that correlates with relative anterior-posterior cell position. One of the extracellular cues is provided by the F and U cells, which promote anterior fates. We show that the genes in the lin-3/let-23 signalling pathway required for hermaphrodite vulval induction also mediate this F/U signal. Reduction-of-function mutations in lin-3, let-23, sem-5, let-60 or lin-45 disrupt the fate of anterior cells. Likewise, activation of the pathway with ubiquitously produced signal results in posterior cells inappropriately adopting the anterior fates even in the absence of F and U. We have further used this genetic pathway to begin to understand how multiple positional cues are integrated to specify cell fate. We demonstrate that lin-15 acts in spicule development as it does in vulval induction, as a negative regulator of let-23 receptor activity. A second extracellular cue, from Y.p, also acts antagonistically to the lin-3/let-23 pathway. However, this signal is apparently integrated into the lin-3/let-23 pathway at some step after lin-45 raf and is thus functionally distinct from lin-15. We have also investigated the role of lin-12 in forming the anterior/posterior pattern of fates. A lin-12 gain-of-function defect is masked by redundant positional information from F and U."xsd:string |
| http://purl.uniprot.org/citations/7607066 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.120.10.2713"xsd:string |
| http://purl.uniprot.org/citations/7607066 | http://purl.uniprot.org/core/author | "Sternberg P.W."xsd:string |
| http://purl.uniprot.org/citations/7607066 | http://purl.uniprot.org/core/author | "Chamberlin H.M."xsd:string |
| http://purl.uniprot.org/citations/7607066 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7607066 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/7607066 | http://purl.uniprot.org/core/pages | "2713-2721"xsd:string |
| http://purl.uniprot.org/citations/7607066 | http://purl.uniprot.org/core/title | "The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/7607066 | http://purl.uniprot.org/core/volume | "120"xsd:string |
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