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| http://purl.uniprot.org/citations/7607232 | http://www.w3.org/2000/01/rdf-schema#comment | "Three complementation groups of a pet mutant collection have been found to be composed of respiratory-deficient deficient mutants with lesions in mitochondrial protein synthesis. Recombinant plasmids capable of restoring respiration were cloned by transformation of representatives of each complementation group with a yeast genomic library. The plasmids were used to characterize the complementing genes and to institute disruption of the chromosomal copies of each gene in respiratory-proficient yeast. The sequences of the cloned genes indicate that they code for isoleucyl-, arginyl- and glutamyl-tRNA synthetases. The properties of the mutants used to obtain the genes and of strains with the disrupted genes indicate that all three aminoacyl-tRNA synthetases function exclusively in mitochondrial proteins synthesis. The ISM1 gene for mitochondrial isoleucyl-tRNA synthetase has been localized to chromosome XVI next to UME5. The MSR1 gene for the arginyl-tRNA synthetase was previously located on yeast chromosome VIII. The third gene MSE1 for the mitochondrial glutamyl-tRNA synthetase has not been localized. The identification of three new genes coding for mitochondrial-specific aminoacyl-tRNA synthetases indicates that in Saccharomyces cerevisiae at least 11 members of this protein family are encoded by genes distinct from those coding for the homologous cytoplasmic enzymes."xsd:string |
| http://purl.uniprot.org/citations/7607232 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1995.tb20599.x"xsd:string |
| http://purl.uniprot.org/citations/7607232 | http://purl.uniprot.org/core/author | "Tzagoloff A."xsd:string |
| http://purl.uniprot.org/citations/7607232 | http://purl.uniprot.org/core/author | "Shtanko A."xsd:string |
| http://purl.uniprot.org/citations/7607232 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7607232 | http://purl.uniprot.org/core/name | "Eur J Biochem"xsd:string |
| http://purl.uniprot.org/citations/7607232 | http://purl.uniprot.org/core/pages | "582-586"xsd:string |
| http://purl.uniprot.org/citations/7607232 | http://purl.uniprot.org/core/title | "Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes."xsd:string |
| http://purl.uniprot.org/citations/7607232 | http://purl.uniprot.org/core/volume | "230"xsd:string |
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