| http://purl.uniprot.org/citations/7608156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7608156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7608156 | http://www.w3.org/2000/01/rdf-schema#comment | "Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3) stimulate the proliferation and maturation of myeloid progenitor cells following interaction with heterodimeric receptors that share a common beta subunit required for signal transduction. Our previous studies have demonstrated that GM-CSF and IL-3 activate signaling pathways which converge upon a cAMP response element-binding protein (CREB)-binding site of the human immediate early response gene (early growth response gene-1, egr-1) promoter. Using electromobility supershift assays and antibodies directed against CREB phosphorylated on serine 133, we show that CREB is phosphorylated on serine 133 in response to GM-CSF or IL-3 stimulation. We demonstrate that phosphorylation of CREB on serine 133 substantially contributes to transcriptional activation of egr-1 in response to GM-CSF but not IL-3. These studies suggest that phosphorylation of CREB may play different roles during signal transduction, resulting in unique and overlapping biological functions in myeloid cells."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.27.15979"xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.27.15979"xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/author | "Sakamoto K.M."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/author | "Sakamoto K.M."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/author | "Lee H.-J.J."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/author | "Lee H.-J.J."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/author | "Mignacca R.C."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/author | "Mignacca R.C."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/pages | "15979-15983"xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/pages | "15979-15983"xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/title | "Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/title | "Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133."xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7608156 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7608156 |
| http://purl.uniprot.org/citations/7608156 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7608156 |
| http://purl.uniprot.org/citations/7608156 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7608156 |
| http://purl.uniprot.org/citations/7608156 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7608156 |