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http://purl.uniprot.org/citations/7615002http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7615002http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7615002http://www.w3.org/2000/01/rdf-schema#comment"A cDNA clone, designated ATAC, was isolated from a collection of human T cell activation genes. Analysis of tissue distribution determined that ATAC mRNA of approximately 0.9 kb is exclusively expressed in activated CD8+ T cells. Induction of the ATAC gene requires stimulation by both phorbol 12-myristate 13-acetate and Ca2+ ionophore A23187 ("two-signal gene") and is fully abrogated by the immunosuppressive agent cyclosporin A. Upon stimulation, ATAC mRNA is detectable within 30 min, maximal expression is seen after 4 h. The polypeptide encoded by the open reading frame of ATAC mRNA is 114 amino acids long with a calculated M(r) of 12.52 kDa. The structural features predict the cleavage and secretion of a mature ATAC protein of approximately 10 kDa from the 12.52-kDa precursor. ATAC is highly similar to a very recently identified murine molecule designated lymphotactin both at the cDNA (73.8% identity) and the protein (61.4% identity) levels, and related to members of the C-C and C-X-C chemokine families. Two variants of the ATAC protein were expressed and tested for chemotaxis and Ca2+ release on a variety of target cells. The ATAC gene was located to chromosome 1q23."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.org/dc/terms/identifier"doi:10.1002/eji.1830250638"xsd:string
http://purl.uniprot.org/citations/7615002http://purl.org/dc/terms/identifier"doi:10.1002/eji.1830250638"xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Mueller S."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Mueller S."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Senger G."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Senger G."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Kroczek R.A."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Kroczek R.A."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Mages H.W."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Mages H.W."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"D'Apuzzo M."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"D'Apuzzo M."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Korthauer U."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Korthauer U."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Dorner B."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/author"Dorner B."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/name"Eur. J. Immunol."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/name"Eur. J. Immunol."xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/pages"1744-1748"xsd:string
http://purl.uniprot.org/citations/7615002http://purl.uniprot.org/core/pages"1744-1748"xsd:string