| http://purl.uniprot.org/citations/7618087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7618087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7618087 | http://www.w3.org/2000/01/rdf-schema#comment | "CD22 is a membrane immunoglobulin (mIg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mIg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mIg. Ligation of CD22 to prevent its coaggregation with mIg lowers the threshold at which mIg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mIg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mIg signaling to anatomic sites rich in T cells."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.7618087"xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.7618087"xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Justement L.B."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Justement L.B."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Delibrias C.C."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Delibrias C.C."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Doody G.M."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Doody G.M."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Fearon D.T."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Fearon D.T."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Matthews R.J."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Matthews R.J."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Thomas M.L."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/author | "Thomas M.L."xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/pages | "242-244"xsd:string |
| http://purl.uniprot.org/citations/7618087 | http://purl.uniprot.org/core/pages | "242-244"xsd:string |