| http://purl.uniprot.org/citations/7621827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7621827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7621827 | http://www.w3.org/2000/01/rdf-schema#comment | "The SH3 binding protein, 3BP-1, was originally cloned as a partial cDNA from an expression library using the Abl SH3 domain as a probe. In addition to an SH3 binding domain, 3BP-1 displayed homology to a class of GTPase activating proteins (GAPs) active against Rac and Rho proteins. We report here a full length cDNA of 3BP-1 which extends the homology to GAP proteins previously noted. 3BP-1 functions in vitro as a GAP with a specificity for Rac-related G proteins. Microinjection of the 3BP-1 protein into serum-starved fibroblasts produces an inhibition of platelet-derived growth factor (PDGF)-induced membrane ruffling mediated by Rac. Co-injection of 3BP-1 with an activated Rac mutant that is unresponsive to GAPs, counter-acts this inhibition. 3BP-1 does not show in vitro activity towards Rho and, in agreement with this finding, microinjection of 3BP-1 into fibroblasts has no effect on lysophosphatidic acid (LPA)-induced stress fiber assembly mediated by Rho. Thus 3BP-1 is a new and specific Rac GAP that can act in cells to counter Rac-mediated membrane ruffling. How its SH3 binding site interacts with its GAP activity remains to be understood."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1995.tb07315.x"xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1995.tb07315.x"xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Baltimore D."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Baltimore D."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Cerione R.A."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Cerione R.A."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Cicchetti P."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Cicchetti P."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Ridley A.J."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/author | "Ridley A.J."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/pages | "3127-3135"xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/pages | "3127-3135"xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/title | "3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/title | "3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/7621827 | http://purl.uniprot.org/core/volume | "14"xsd:string |