| http://purl.uniprot.org/citations/7636247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7636247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7636247 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian low molecular mass protein-7 (LMP-7) gene resides in the class II region of the MHC, and its product is most probably involved, as a component of a proteasome, in the processing of Ags to be presented by the MHC class I molecules. To elucidate the evolution of the LMP-7 gene at both the primary structure and genetic levels, we isolated LMP-7 cDNA clones from amphibian Xenopus laevis, which last shared a common ancestor with mammals 350 x 10(6) years ago. Two distinctive clones, showing an 85% predicted amino acid sequence identity with each other and 69 to 72% identity with human and mouse LMP-7, were identified from a liver cDNA library of outbred frogs and named XeLMP-7A and XeLMP-7B. XeLMP-7A- and XeLMP-7B-specific probes were used to detect the corresponding genes by using partially inbred frogs with known MHC haplotypes. DNA of the g and j haplotypes hybridized with the XeLMP-7A probe, whereas the f and r haplotype DNA hybridized with the XeLMP-7B probe. These hybridization patterns cosegregated with the MHC haplotypes among offspring of an f/f x f/g cross, and one recombinant revealed that the LMP-7 gene is linked more closely to class II than to class I or class III genes. Taken together, the data indicate that XeLMP-7A and XeLMP-7B are highly diverse alleles at a single locus in the frog MHC. The great allelic diversity can be explained either by coselection with particular class I alleles or by differential silencing of MHC genes in the polyploid X. laevis."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Kato Y."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Kato Y."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Sasaki M."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Sasaki M."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Flajnik M.F."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Flajnik M.F."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Namikawa C."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Namikawa C."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Salter-Cid L."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Salter-Cid L."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Nonaka M."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/author | "Nonaka M."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/pages | "1964-1971"xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/pages | "1964-1971"xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/title | "Isolation of Xenopus LMP-7 homologues. Striking allelic diversity and linkage to MHC."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/title | "Isolation of Xenopus LMP-7 homologues. Striking allelic diversity and linkage to MHC."xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/volume | "155"xsd:string |
| http://purl.uniprot.org/citations/7636247 | http://purl.uniprot.org/core/volume | "155"xsd:string |