| http://purl.uniprot.org/citations/7641683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7641683 | http://www.w3.org/2000/01/rdf-schema#comment | "The exocytotic release of potent hormones is a tightly controlled process. Its direct regulation without the involvement of second messengers would ensure rapid signal processing. In streptolysin O-permeabilized insulin-secreting cells, a preparation allowing dialysis of cytosolic macromolecules, activation of alpha 2-adrenergic receptors caused pertussis toxin-sensitive inhibition of calcium-induced exocytosis. This inhibition was mimicked very efficiently by the use of specific receptor-mimetic peptides, indicating the involvement of Gi and, to a lesser extent, of G(o). The regulation was exerted beyond the ATP-dependent step of exocytosis. In addition, low nanomolar amounts of pre-activated Gi/G(o) directly inhibited exocytosis. As transient overexpression of constitutively active mutants of G alpha i1, G alpha i2, G alpha i3 and G alpha o2 but not of G alpha o1 reproduced this regulation, the G alpha subunit alone is sufficient to induce inhibition. These results define exocytosis as an effector for heterotrimeric G-proteins and delineate the properties of the transduction pathway."xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1995.tb00033.x"xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/author | "Okamoto T."xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/author | "Lang J."xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/author | "Nishimoto I."xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/author | "Regazzi R."xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/author | "Wollheim C.B."xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/author | "Weller U."xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/author | "Kiraly C."xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/pages | "3635-3644"xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/title | "Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits."xsd:string |
| http://purl.uniprot.org/citations/7641683 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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