| http://purl.uniprot.org/citations/7642581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7642581 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously, we have identified p120 as a Fyn/Lck SH3 and SH2 domain-binding protein that is tyrosine phosphorylated rapidly after T cell receptor triggering. Here, we used direct protein purification, amino acid sequence analysis, reactivity with antibodies, and two-dimensional gel analyses to identify p120 as the human c-cbl protooncogene product. We demonstrate in vivo complexes of p120cbl with Fyn tyrosine kinase, the adaptor protein Grb2, and the p85 subunit of phosphatidylinositol (PI) 3-kinase. The association of p120cbl with Fyn and the p85 subunit of PI 3-kinase (together with PI 3-kinase activity) was markedly increased by T cell activation, consistent with in vitro binding of p120cbl to their SH2 as well as SH3 domains. In contrast, a large fraction of p120cbl was associated with Grb2 prior to activation, and this association did not change upon T cell activation. In vitro, p120cbl interacted with Grb2 exclusively through its SH3 domains. These results demonstrate a novel Grb2-p120cbl signaling complex in T cells, distinct from the previously analyzed Grb2-Sos complex. The association of p120cbl with ubiquitous signaling proteins strongly suggests a general signal transducing function for this enigmatic protooncogene with established leukemogenic potential but unknown physiological function."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.32.19141"xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/author | "Druker B."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/author | "Fukazawa T."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/author | "Shoelson S.E."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/author | "Cantley L."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/author | "Band H."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/author | "Reedquist K.A."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/author | "Panchamoorthy G."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/author | "Soltoff S."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/author | "Trub T."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/pages | "19141-19150"xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/title | "The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase."xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7642581 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7642581 |
| http://purl.uniprot.org/citations/7642581 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7642581 |
| http://purl.uniprot.org/uniprot/#_Q07889-mappedCitation-7642581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7642581 |
| http://purl.uniprot.org/uniprot/#_P06241-mappedCitation-7642581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7642581 |
| http://purl.uniprot.org/uniprot/#_P27986-mappedCitation-7642581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7642581 |
| http://purl.uniprot.org/uniprot/#_P22681-mappedCitation-7642581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7642581 |
| http://purl.uniprot.org/uniprot/#_P62993-mappedCitation-7642581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7642581 |
| http://purl.uniprot.org/uniprot/P22681 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7642581 |