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http://purl.uniprot.org/citations/7654366http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7654366http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7654366http://www.w3.org/2000/01/rdf-schema#comment"The effect of growth factors on regulating gene expression in the preimplantation mouse embryo was examined, since results of previous experiments revealed a stimulatory effect of exogenously-added growth factors on preimplantation development in vitro. Treatment of early cavitating blastocysts with either 250 pM TGF-alpha or TGF-beta results in changes in the pattern of total protein synthesis as assessed by high-resolution two-dimensional gel electrophoresis. In some cases, the synthesis of a particular polypeptide is either up- or downregulated by each growth factor, whereas in other instances the synthesis of a polypeptide is modulated by one but not the other growth factor. Use of the mRNA differential display method permitted the identification of genes whose expression is either up- or downregulated by these growth factors. Treatment of mouse blastocysts with either TGF-alpha or TGF-beta results in the increased expression of the b subunit of the F0ATPase. TGF-beta also stimulates the expression of the DNA polymerase alpha. TGF-alpha treatment results in the increase in expression of a gene homologous to the human HEPG2 cDNA, as well as in a decrease in expression of fibronectin."xsd:string
http://purl.uniprot.org/citations/7654366http://purl.org/dc/terms/identifier"doi:10.1002/mrd.1080410203"xsd:string
http://purl.uniprot.org/citations/7654366http://purl.org/dc/terms/identifier"doi:10.1002/mrd.1080410203"xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/author"Schultz R.M."xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/author"Schultz R.M."xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/author"Babalola G.O."xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/author"Babalola G.O."xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/name"Mol. Reprod. Dev."xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/name"Mol. Reprod. Dev."xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/pages"133-139"xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/pages"133-139"xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/title"Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta."xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/title"Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta."xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/volume"41"xsd:string
http://purl.uniprot.org/citations/7654366http://purl.uniprot.org/core/volume"41"xsd:string
http://purl.uniprot.org/citations/7654366http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/7654366
http://purl.uniprot.org/citations/7654366http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/7654366
http://purl.uniprot.org/citations/7654366http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/7654366
http://purl.uniprot.org/citations/7654366http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/7654366
http://purl.uniprot.org/uniprot/Q64218http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/7654366
http://purl.uniprot.org/uniprot/Q3UB74http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/7654366