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http://purl.uniprot.org/citations/7664066http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7664066http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7664066http://www.w3.org/2000/01/rdf-schema#comment"The crystal structure of the dimeric PvuII restriction endonuclease (R.PvuII) has been determined at a resolution of 2.4A. The protein has a mixed alpha/beta architecture and consists of two subdomains. Despite a lack of sequence homology, extensive structural similarities exist between one R.PvuII subdomain and the DNA-binding subdomain of EcoRV endonuclease (R.EcoRV); the dimerization subdomains are unrelated. Within the similar domains, flexible segments of R.PvuII are topologically equivalent to the DNA-binding turns of R.EcoRV; potential catalytic residues can be deduced from the structural similarities to R.EcoRV. Conformational flexibility is important for the interaction with DNA. A possible classification of endonuclease structures on the basis of the positions of the scissile phosphates is discussed."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.org/dc/terms/identifier"doi:10.1038/nsb0794-469"xsd:string
http://purl.uniprot.org/citations/7664066http://purl.org/dc/terms/identifier"doi:10.1038/nsb0794-469"xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Wilson K.S."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Wilson K.S."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Tucker P.A."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Tucker P.A."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Athanasiadis A."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Athanasiadis A."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Kokkinidis M."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Kokkinidis M."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Kotsifaki D."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Kotsifaki D."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Vlassi M."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/author"Vlassi M."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/name"Nat. Struct. Biol."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/name"Nat. Struct. Biol."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/pages"469-475"xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/pages"469-475"xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/title"Crystal structure of PvuII endonuclease reveals extensive structural homologies to EcoRV."xsd:string
http://purl.uniprot.org/citations/7664066http://purl.uniprot.org/core/title"Crystal structure of PvuII endonuclease reveals extensive structural homologies to EcoRV."xsd:string