| http://purl.uniprot.org/citations/7664647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7664647 | http://www.w3.org/2000/01/rdf-schema#comment | "A new member of the transforming growth factor (TGF)-beta superfamily, BMP-9, has recently been identified and shown to be expressed in the developing mouse liver. This report demonstrates that human HepG2 liver tumor cells bind recombinant human BMP-9 (rhBMP-9) with high affinity. Cross-linking analysis indicates that HepG2 cells express two BMP-9 receptors of approximately 54 and 80 kilodaltons, similar in size to the Type I and Type II receptors reported by others for TGF-beta and BMP-4. However, cross-competition experiments demonstrate that the BMP-9 receptors on HepG2 cells do not bind other BMPs or TGF-beta s, indicating that these are novel receptors with binding specificity for BMP-9. In functional studies, rhBMP-9 stimulates HepG2 cell proliferation as indicated by [3H]thymidine incorporation and cell counting assays. A proliferative effect of rh-BMP-9 was also observed on primary rat hepatocytes. In contrast, TGF-beta had no effect on HepG2 cell proliferation and inhibited proliferation in primary hepatocytes. These results suggest that BMP-9, acting through a novel set of receptors, may play a regulatory role in hepatic growth and function."xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.org/dc/terms/identifier | "doi:10.1210/endo.136.10.7664647"xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/author | "Song J.J."xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/author | "Rosen V."xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/author | "Jirtle R.L."xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/author | "Celeste A.J."xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/author | "Thies R.S."xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/author | "Kong F.M."xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/pages | "4293-4297"xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/title | "Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation."xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/7664647 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7664647 |
| http://purl.uniprot.org/citations/7664647 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7664647 |
| http://purl.uniprot.org/uniprot/Q9UK05#attribution-E1717607778AD7113D4DD33B670C0786 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7664647 |
| http://purl.uniprot.org/uniprot/#_Q9WV56-mappedCitation-7664647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7664647 |
| http://purl.uniprot.org/uniprot/Q9WV56 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/7664647 |