| http://purl.uniprot.org/citations/7669718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7669718 | http://www.w3.org/2000/01/rdf-schema#comment | "Treatment of M1 myeloid leukemic cells with interleukin 6 (IL-6) or dexamethasone (DEX), both of which induce differentiation in these cells, down-regulated expression of the apoptosis-suppressing gene bcl-2 and the apoptosis-promoting gene bax but up-regulated expression of the apoptosis-suppressing gene bcl-XL. There was a higher expression of bcl-XL in cells treated with DEX or DEX plus IL-6 compared to cells treated with IL-6 alone. The alternatively spliced bcl-X gene, bcl-Xs, which interferes with the action of bcl-2, was not expressed. Treatment with IL-6 increased the susceptibility of these cells to induction of apoptosis by Adriamycin or cycloheximide, but treatment with DEX or with IL-6 and DEX did not. Withdrawal of DEX after up-regulation of bcl-XL resulted in a decrease in bcl-XL expression and a concomitant increase in cell susceptibility to induction of apoptosis. Another myeloid leukemia that shows barely detectable expression of bcl-2 also showed up-regulated expression of bcl-XL but no change in bax after induction of differentiation with granulocyte-macrophage colony-stimulating factor, and this reduced cell susceptibility to induction of apoptosis by Adriamycin or cycloheximide. The results indicate that the related apoptosis-regulating genes bcl-2, bcl-XL, and bax are differently regulated and that up-regulation of bcl-XL expression may compensate for down-regulation of bcl-2 in the balance between genes that control apoptosis."xsd:string |
| http://purl.uniprot.org/citations/7669718 | http://purl.uniprot.org/core/author | "Sachs L."xsd:string |
| http://purl.uniprot.org/citations/7669718 | http://purl.uniprot.org/core/author | "Lotem J."xsd:string |
| http://purl.uniprot.org/citations/7669718 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7669718 | http://purl.uniprot.org/core/name | "Cell Growth Differ"xsd:string |
| http://purl.uniprot.org/citations/7669718 | http://purl.uniprot.org/core/pages | "647-653"xsd:string |
| http://purl.uniprot.org/citations/7669718 | http://purl.uniprot.org/core/title | "Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone."xsd:string |
| http://purl.uniprot.org/citations/7669718 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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