| http://purl.uniprot.org/citations/7670465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7670465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7670465 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the generation and characterization of mice lacking adenosine deaminase (ADA). In humans, absence of ADA causes severe combined immunodeficiency. In contrast, ADA-deficient mice die perinatally with marked liver-cell degeneration, but lack abnormalities in the thymus. The ADA substrates, adenosine and deoxyadenosine, are increased in ADA-deficient mice. Adenine deoxyribonucleotides are only modestly elevated, whereas S-adenosylhomocysteine hydrolase activity is reduced more than 85%. Consequently, the ratio of S-adenosylhomocysteine (AdoMet) to S-adenosyl homocysteine (AdoHcy) is reduced threefold in liver. We conclude that ADA plays a more critical role in murine than human fetal development. The murine liver pathology may be due to AdoHcy-mediated inhibition of AdoMet-dependent transmethylation reactions."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng0795-279"xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng0795-279"xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Hershfield M.S."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Hershfield M.S."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Zurcher C."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Zurcher C."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Berns A."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Berns A."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Breuer M.L."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Breuer M.L."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Migchielsen A.A."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Migchielsen A.A."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Ossendorp F."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Ossendorp F."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Toutain S."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Toutain S."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Valerio D."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "Valerio D."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "te Riele H."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "te Riele H."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "van Roon M.A."xsd:string |
| http://purl.uniprot.org/citations/7670465 | http://purl.uniprot.org/core/author | "van Roon M.A."xsd:string |