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http://purl.uniprot.org/citations/7671308http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7671308http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7671308http://www.w3.org/2000/01/rdf-schema#comment"While significant progress has been made in understanding the molecular events underlying the early specification of the antero-posterior and dorso-ventral axes, little information is available regarding the cellular or molecular basis for left-right (LR) differences in animal morphogenesis. We describe the expression patterns of three genes involved in LR determination in chick embryos: activin receptor IIa, Sonic hedgehog (Shh), and cNR-1 (related to the mouse gene nodal). These genes are expressed asymmetrically during and after gastrulation and regulate the expression of one another in a sequential pathway. Moreover, manipulation of the sidedness of either activin protein or Shh expression alters heart situs. Together, these observations identify a cascade of molecular asymmetry in that determines morphological LR asymmetry in the chick embryo."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(95)90477-8"xsd:string
http://purl.uniprot.org/citations/7671308http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(95)90477-8"xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Johnson R.L."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Johnson R.L."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Levin M."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Levin M."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Stern C.D."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Stern C.D."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Kuehn M."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Kuehn M."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Tabin C."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/author"Tabin C."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/pages"803-814"xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/pages"803-814"xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/title"A molecular pathway determining left-right asymmetry in chick embryogenesis."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/title"A molecular pathway determining left-right asymmetry in chick embryogenesis."xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/volume"82"xsd:string
http://purl.uniprot.org/citations/7671308http://purl.uniprot.org/core/volume"82"xsd:string