| http://purl.uniprot.org/citations/7678994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7678994 | http://www.w3.org/2000/01/rdf-schema#comment | "Tal-1 rearrangements are associated with nearly 30% of human T acute lymphoblastic leukemia. Tal-1 gene encodes a putative transcription factor with a basic helix-loop-helix domain and is known to be predominantly expressed in hematopoietic cells. We investigated the pattern of tal-1 expression in purified human hematopoietic cells by in situ hybridization and reverse transcriptase polymerase chain reaction analysis. Both methods demonstrated that the tal-1 gene is expressed in megakaryocytes and erythroblasts as well as in basophilic granulocytes. In addition, our results indicate that the tal-1 1A promoter, which contains two consensus GATA-binding sites, is active mainly in these lineages. Because the GATA-1 gene is known to transactivate several genes specific for the erythroid, megakaryocytic, and mastocytic/basophilic lineages, we studied GATA-1 expression in these purified hematopoietic cells. We found that GATA-1 and tal-1 genes are coexpressed in these three lineages. Remarkably, the expression of both genes is downmodulated during erythroid and megakaryocytic terminal maturation. In immature hematopoietic cells, tal-1 and GATA-1 genes are coexpressed in committed progenitors cells (CD34+/CD38(2+)), whereas they are not detectable in the most primitive cells (CD34(2+)/CD38-). In contrast, GATA-2 is strongly expressed in both most primitive and committed progenitors cells, whereas GATA-3 is mostly detected in most primitive ones. Altogether our results strongly suggest that GATA-1 modulates the transcription of tal-1 during the differentiation of the erythroid, megakaryocytic, and basosophilic lineages."xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/author | "Bernard O."xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/author | "Romeo P.H."xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/author | "Vainchenker W."xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/author | "Mitjavila M.T."xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/author | "Mathieu-Mahul D."xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/author | "Mouthon M.A."xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/pages | "647-655"xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/title | "Expression of tal-1 and GATA-binding proteins during human hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/7678994 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7678994 |
| http://purl.uniprot.org/citations/7678994 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7678994 |
| http://purl.uniprot.org/uniprot/P15976#attribution-4528062FBDC454540132FCC862162D2E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7678994 |
| http://purl.uniprot.org/uniprot/P17542#attribution-4528062FBDC454540132FCC862162D2E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7678994 |