| http://purl.uniprot.org/citations/7680960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7680960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7680960 | http://www.w3.org/2000/01/rdf-schema#comment | "The crystal structure of the Src SH2 domain complexed with a high affinity 11-residue phosphopeptide has been determined at 2.7 A resolution by X-ray diffraction. The peptide binds in an extended conformation and makes primary interactions with the SH2 domain at six central residues: PQ(pY)EEI. The phosphotyrosine and the isoleucine are tightly bound by two well-defined pockets on the protein surface, resulting in a complex that resembles a two-pronged plug engaging a two-holed socket. The glutamate residues are in solvent-exposed environments in the vicinity of basic side chains of the SH2 domain, and the two N-terminal residues cap the phosphotyrosine-binding site. The crystal structure of Src SH2 in the absence of peptide has been determined at 2.5 A resolution, and comparison with the structure of the high affinity complex reveals only localized and relatively small changes."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(93)90405-f"xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(93)90405-f"xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Kuriyan J."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Kuriyan J."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Cowburn D."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Cowburn D."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Waksman G."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Waksman G."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Shoelson S.E."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Shoelson S.E."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Pant N."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/author | "Pant N."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/pages | "779-790"xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/pages | "779-790"xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/title | "Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/title | "Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms."xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/7680960 | http://purl.uniprot.org/core/volume | "72"xsd:string |