| http://purl.uniprot.org/citations/7681402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7681402 | http://www.w3.org/2000/01/rdf-schema#comment | "The B cell antigen receptor is a complex containing the antigen-binding immunoglobulin molecules and the Ig-alpha/Ig-beta heterodimer which presumably connects the B cell antigen receptor to intracellular signaling components. To analyze the functional properties of the cytoplasmic parts of the B cell antigen receptor, we used the K46 B lymphoma line (IgG2a, kappa) to express chimeric molecules composed of the extracellular and transmembrane part of the CD8 alpha molecule and the cytoplasmic sequence of either the Ig-alpha (CD8 alpha/Ig-alpha), the Ig-beta (CD8 alpha/Ig-beta) protein or the membrane-bound gamma 2a heavy chain (CD8 alpha/gamma 2a). From these three types of chimeric molecules only (CD8 alpha/Ig-alpha and CD8 alpha/Ig-beta, but not CD8 alpha/gamma 2a, could transduce signals, thus providing the first evidence that the cytoplasmic tail of Ig-alpha and Ig-beta have a signaling capacity. After cross-linking with anti-CD8 alpha antibodies, both molecules induced a similar increase in intracellular free calcium ion and in MAP kinase phosphorylation. Protein tyrosine kinases, however, were strongly activated via the CD8 alpha/Ig-alpha and only marginally via the CD8 alpha/Ig-beta molecule. This suggests that the Ig-alpha and Ig-beta proteins have distinct roles during signal transduction through the B cell antigen receptor."xsd:string |
| http://purl.uniprot.org/citations/7681402 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.1830230422"xsd:string |
| http://purl.uniprot.org/citations/7681402 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/7681402 | http://purl.uniprot.org/core/author | "Kim K.M."xsd:string |
| http://purl.uniprot.org/citations/7681402 | http://purl.uniprot.org/core/author | "Alber G."xsd:string |
| http://purl.uniprot.org/citations/7681402 | http://purl.uniprot.org/core/author | "Weiser P."xsd:string |
| http://purl.uniprot.org/citations/7681402 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7681402 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/7681402 | http://purl.uniprot.org/core/pages | "911-916"xsd:string |
| http://purl.uniprot.org/citations/7681402 | http://purl.uniprot.org/core/title | "Differential signaling through the Ig-alpha and Ig-beta components of the B cell antigen receptor."xsd:string |
| http://purl.uniprot.org/citations/7681402 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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