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| http://purl.uniprot.org/citations/7684502 | http://www.w3.org/2000/01/rdf-schema#comment | "Hsp83 is the Drosophila homolog of the mammalian Hsp90 family of regulatory molecular chaperones. We show that maternally synthesized Hsp83 transcripts are localized to the posterior pole of the early Drosophila embryo by a novel mechanism involving a combination of generalized RNA degradation and local protection at the posterior. This protection of Hsp83 RNA occurs in wild-type embryos and embryos produced by females carrying the maternal effect mutations nanos and pumilio, which eliminate components of the posterior polar plasm without disrupting polar granule integrity. In contrast, Hsp83 RNA is not protected at the posterior pole of embryos produced by females carrying maternal mutations that disrupt the posterior polar plasm and the polar granules--cappuccino, oskar, spire, staufen, tudor, valois, and vasa. Mislocalization of oskar RNA to the anterior pole, which has been shown to result in induction of germ cells at the anterior, leads to anterior protection of maternal Hsp83 RNA. These results suggest that Hsp83 RNA is a component of the posterior polar plasm that might be associated with polar granules. In addition, we show that zygotic expression of Hsp83 commences in the anterior third of the embryo at the syncytial blastoderm stage and is regulated by the anterior morphogen, bicoid. We consider the possible developmental significance of this complex control of Hsp83 transcript distribution."xsd:string |
| http://purl.uniprot.org/citations/7684502 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.13.6.3773-3781.1993"xsd:string |
| http://purl.uniprot.org/citations/7684502 | http://purl.uniprot.org/core/author | "Ding D."xsd:string |
| http://purl.uniprot.org/citations/7684502 | http://purl.uniprot.org/core/author | "Parkhurst S.M."xsd:string |
| http://purl.uniprot.org/citations/7684502 | http://purl.uniprot.org/core/author | "Lipshitz H.D."xsd:string |
| http://purl.uniprot.org/citations/7684502 | http://purl.uniprot.org/core/author | "Halsell S.R."xsd:string |
| http://purl.uniprot.org/citations/7684502 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7684502 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/7684502 | http://purl.uniprot.org/core/pages | "3773-3781"xsd:string |
| http://purl.uniprot.org/citations/7684502 | http://purl.uniprot.org/core/title | "Dynamic Hsp83 RNA localization during Drosophila oogenesis and embryogenesis."xsd:string |
| http://purl.uniprot.org/citations/7684502 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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