Results
Your Query
▶
▶
| Subject | Predicate | Object |
|---|---|---|
| http://purl.uniprot.org/citations/7688032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7688032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7688032 | http://www.w3.org/2000/01/rdf-schema#comment | "The partial sequence of a gene encoding the COOH terminus of a protein of apparent molecular weight of 160 kD associated with the flagellum of trypomastigotes of Trypanosoma cruzi (FL-160 now renamed to FL-160-1) has been previously reported. The COOH terminus of FL-160-1 has an epitope, defined by 12 amino acids, which molecularly miMics a nervous tissue antigen of 48 kD found in myenteric plexus, sciatic nerve, and a subset of cells in the central nervous system. We now report that FL-160 is a family of highly related genes. The sequence has been determined for the entire open reading frame (ORF) of one of the members of the FL-160 gene family (FL-160-2) and three other partial ORFs. Sequence analysis reveals the various members of the FL-160 gene family to be approximately 80% homologous in the predicted amino acid sequence, but all retain the 12-amino acid molecular mimicry epitope on the COOH terminus. Comparison of the sequence of FL-160-2 to other sequences demonstrates amino acid homology to bacterial sialidase (27%), members of the SA85 gene family (25-30%) and the shed acute-phase antigen/neuraminidase/trans-sialidase gene family (25-30%). Quantitative hybridization at high stringency suggests 750 copies of FL-160 are present in the DNA of each parasite. Reverse transcription and sequence analysis demonstrates that at least five of the members of the FL-160 gene family are transcribed. The NH2 terminus of one of the FL-160 gene products was expressed and antibodies prepared. Antibodies directed to either the COOH or the NH2 terminus of FL-160 bind a 160-kD T. cruzi protein. Both antibodies bind the surface membrane in the flagellar pocket of the trypomastigote. Antibodies to the NH2 terminus bind epineurium and scattered linear densities in sciatic nerve in a pattern distinct from the pattern with antibodies to the COOH terminus. Thus, there are at least two distinct molecular mimicry epitopes on the FL-160 molecule and both mimic epitopes found in nervous tissues. FL-160 may be involved in the generation of autoimmunity to nervous tissues by molecular mimicry, observed in chronic Chagas' disease."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.178.2.681"xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.178.2.681"xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/author | "Van Voorhis W.C."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/author | "Van Voorhis W.C."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/author | "Koelling R."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/author | "Koelling R."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/author | "Barrett L."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/author | "Barrett L."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/author | "Farr A.G."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/author | "Farr A.G."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/pages | "681-694"xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/pages | "681-694"xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/title | "FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/title | "FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues."xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/7688032 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7688032 |
| http://purl.uniprot.org/citations/7688032 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7688032 |