| http://purl.uniprot.org/citations/7690439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7690439 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 12 (IL-12: natural killer cell stimulatory factor, NKSF; cytotoxic lymphocyte maturation factor, CLMF) was studied for its effect on colony formation and lineage expression of low-density bone marrow cells from 5-fluorouracil-treated mice, and of sorted stem cells using a semi-solid culture assay in the absence or presence of IL-3, IL-11, Steel factor (SF) and erythropoietin. IL-12 did not support colony formation as a single factor, nor in the presence of IL-11 or SF. In IL-3-containing cultures, IL-12 slightly enhanced neutrophilic and monocyte differentiation. Both SF and IL-11 synergized with IL-3 to increase the percentage of multilineage colonies and the number of colonies containing erythrocytes, megakaryocytes, neutrophils, eosinophils, monocytes/macrophages, and blast cells, but not mast cells. In the presence of IL-3 + IL-11, IL-12 greatly enhanced neutrophil, megakaryocyte, erythrocyte, and mast cell development. In IL-3 + SF-containing cultures, IL-12 further increased colony numbers and a higher percentage of colonies expressed neutrophilic, megakaryocytic, erythroid, monocytic, blast cell, and/or mast cell lineages. Colony size and the presence of eosinophils in colonies were unaffected by IL-12 addition. These effects of IL-12 could not be reversed by antibodies against interferon-gamma. Our data show that IL-12 may act as a synergistic factor, stimulating multilineage expression of hemopoietic stem cells, probably via a direct action. The observed activity of IL-12, however, required the presence of a least two factors, i.e. either IL-3 + IL-11, or IL-3 + SF."xsd:string |
| http://purl.uniprot.org/citations/7690439 | http://purl.uniprot.org/core/author | "Neben S."xsd:string |
| http://purl.uniprot.org/citations/7690439 | http://purl.uniprot.org/core/author | "Ploemacher R.E."xsd:string |
| http://purl.uniprot.org/citations/7690439 | http://purl.uniprot.org/core/author | "Boudewijn A."xsd:string |
| http://purl.uniprot.org/citations/7690439 | http://purl.uniprot.org/core/author | "van Soest P.L."xsd:string |
| http://purl.uniprot.org/citations/7690439 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7690439 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/7690439 | http://purl.uniprot.org/core/pages | "1374-1380"xsd:string |
| http://purl.uniprot.org/citations/7690439 | http://purl.uniprot.org/core/title | "Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor."xsd:string |
| http://purl.uniprot.org/citations/7690439 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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