| http://purl.uniprot.org/citations/7690548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7690548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7690548 | http://www.w3.org/2000/01/rdf-schema#comment | "Furin has been proposed to be the endoprotease responsible for precursor cleavage at Arg-X-Lys/Arg-Arg (RXK/RR) sites within the constitutive secretory pathway. However, there was a possibility that other protease(s) is involved in this cleavage. We here characterized furin in human colon carcinoma LoVo cells, since these cells lacked the endogenous processing activity toward RXK/RR sites and recovered the activity by transfection of furin cDNA. Furin cDNA cloned from LoVo cells had one nucleotide deletion in the region covering the homo B domain which is essential for the endoproteolytic activity. LoVo cells transfected with a furin construct with the mutation showed no activity. Based on these data, we conclude that furin is the endoprotease that is involved in the precursor cleavage at RXK/RR sites within the constitutive secretory pathway."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1993.2146"xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1993.2146"xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Murakami K."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Murakami K."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Takahashi S."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Takahashi S."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Ikehara Y."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Ikehara Y."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Misumi Y."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Misumi Y."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Hatsuzawa K."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Hatsuzawa K."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Kitamura N."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Kitamura N."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Kasai K."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/author | "Kasai K."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/7690548 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |