| http://purl.uniprot.org/citations/7706298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7706298 | http://www.w3.org/2000/01/rdf-schema#comment | "A strong T cell-specific enhancer is located 3' to the human CD2 gene. Six sequences within this enhancer are bound by proteins present in T cell nuclear extracts. These sequences share homology with sequences bound by several transcription factors involved in T cell- and lymphoid-specific transcription. The results presented here demonstrate that the human T cell-specific transcription factor, SOX4, is able to bind to one of these regions; further, SOX4 transactivates transcription of a reporter gene via three tandem copies of this sequence. The binding of SOX4 to this site is not via a canonical HMG protein binding sequence, identifying a novel class of binding site for this protein. A second sequence within the CD2 enhancer closely resembles the IL-2 NF-AT site. We show that it is bound by the ets-related factor, Elf1. However, unlike the IL-2 NF-AT sequence, the CD2 NF-AT-like sequence is unable to confer transcriptional inducibility on a reporter gene. Consistent with this result, we show that the observed increase in expression of CD2 protein on the cell surface following T cell activation is a post-transcriptional event."xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.13.7515"xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://purl.uniprot.org/core/author | "Owen M.J."xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://purl.uniprot.org/core/author | "Lake R.A."xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://purl.uniprot.org/core/author | "Wotton D."xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://purl.uniprot.org/core/author | "Farr C.J."xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7706298 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://purl.uniprot.org/core/pages | "7515-7522"xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://purl.uniprot.org/core/title | "The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer."xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7706298 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7706298 |
| http://purl.uniprot.org/citations/7706298 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7706298 |
| http://purl.uniprot.org/uniprot/Q06945#attribution-9D4E05AC884380479895BB23A8E5352A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7706298 |