| http://purl.uniprot.org/citations/7711063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7711063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7711063 | http://www.w3.org/2000/01/rdf-schema#comment | "Oct-1 is a ubiquitously expressed regulatory gene of the POU domain family. The Oct-1 protein binds to the octamer motif present in the control regions of a variety of genes such as the immunoglobulins, histone H2B and snRNAs. To learn about Oct-1 and its possible role in B-cell maturation, we have used oct-2 cDNA to screen a murine pre-B cell, cDNA library. Two cDNA clones were identical in their POU-homeo box DNA binding domain, but differed in their 3'-region. Whereas one clone (oct-1a) was very similar to its human oct-1 homologue, the other (oct-1b), contained an additional 72 bp sequence (designated E1) at the serine threonine rich coding region (position 1485 of the human oct-1), and a deletion of another 72 bp sequence (designated E2) downstream (position 1920). These changes preserve the protein reading frame. DNA blot analysis indicates that murine oct-1 is a single copy gene and that the two oct-1 isoforms oct-1 is expressed as a large approximately 10 kb transcript in all the cell are generated by alternative RNA splicing. RNA blots showed that oct-1 is expressed as a large approximately 10 kb transcript in all the cell lines tested. PCR analysis of the E1 and E2 72 bp regions, indicated the presence of a third isoform containing both E1 and E2 (Oct-1c). Oct-1a and Oct-1b were present in all cell types examined, but the level of expression was lower in liver and spleen as compared to testis, thymus and kidney. The ratio of Oct-1b to Oct-1a ranged between 0.2 to 0.5, for all tissues examined except for testis which expressed higher amounts of oct-1b and/or oct-1c. Our findings thus show that the pattern of expression of the oct-1 gene is more complex than hitherto thought."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.org/dc/terms/identifier | "doi:10.1016/0167-4781(94)00246-y"xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.org/dc/terms/identifier | "doi:10.1016/0167-4781(94)00246-y"xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Laskov R."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Laskov R."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Hasin T."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Hasin T."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Hochberg M."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Hochberg M."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Jaffe J."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Jaffe J."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Reich L."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Reich L."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Riss J."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/author | "Riss J."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/pages | "201-209"xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/pages | "201-209"xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/title | "Cloning, sequencing and expression of two isoforms of the murine oct-1 transcription factor."xsd:string |
| http://purl.uniprot.org/citations/7711063 | http://purl.uniprot.org/core/title | "Cloning, sequencing and expression of two isoforms of the murine oct-1 transcription factor."xsd:string |