| http://purl.uniprot.org/citations/7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7715727 | http://www.w3.org/2000/01/rdf-schema#comment | "The oncogene bmi-1, which was originally found to be involved in B- and T-cell lymphoma formation encodes a protein with a domain of homology to the Drosophila protein Posterior sex combs (Psc) and its relative Suppressor 2 of Zeste (Su(z)2) (refs 4 and 5). Psc is a member of the Polycomb-group gene family, which is required to maintain the repression of homeotic genes that regulate the identities of Drosophila segments. The possibility that bmi-1 may play a similar role in vertebrates was suggested by our previous finding that mice lacking the bmi-1 gene show posterior transformations of the axial skeleton. Here we report that transgenic mice overexpressing Bmi-1 protein show the opposite phenotype, namely a dose-dependent anterior transformation of vertebral identity. The anterior expression boundary of the Hoxc-5 gene is shifted in the posterior direction, indicating that Bmi-1 is involved in the repression of Hox genes. We propose that Bmi-1 is a member of a vertebrate Polycomb complex that regulates segmental identity by repressing Hox genes throughout development."xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.org/dc/terms/identifier | "doi:10.1038/374724a0"xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/author | "Berns A."xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/author | "Alkema M.J."xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/author | "van Lohuizen M."xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/author | "van der Lugt N.M."xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/author | "Bobeldijk R.C."xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/pages | "724-727"xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/title | "Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://purl.uniprot.org/core/volume | "374"xsd:string |
| http://purl.uniprot.org/citations/7715727 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7715727 |
| http://purl.uniprot.org/citations/7715727 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7715727 |
| http://purl.uniprot.org/uniprot/P35226#attribution-2BDE2616859E9B2BD28A5F00BD6DD8A1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7715727 |
| http://purl.uniprot.org/uniprot/#_E9Q606-mappedCitation-7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715727 |
| http://purl.uniprot.org/uniprot/#_A1E281-mappedCitation-7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715727 |
| http://purl.uniprot.org/uniprot/#_A2ASR5-mappedCitation-7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715727 |
| http://purl.uniprot.org/uniprot/#_A2ASR6-mappedCitation-7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715727 |
| http://purl.uniprot.org/uniprot/#_A2ASR7-mappedCitation-7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715727 |
| http://purl.uniprot.org/uniprot/#_A2ASR8-mappedCitation-7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715727 |
| http://purl.uniprot.org/uniprot/#_B2RRX1-mappedCitation-7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715727 |
| http://purl.uniprot.org/uniprot/#_E9Q1F2-mappedCitation-7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715727 |
| http://purl.uniprot.org/uniprot/#_E9Q2D1-mappedCitation-7715727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715727 |